Plasma S100A8 and S100A9 Are Strong Prognostic Factors for Hepatitis B Virus-Related Acute-on-Chronic Liver Failure

Objectives. The rapidly evolving organ failure and high short-run mortality of acute-on-chronic liver (ACLF) are inseparable from the role systemic inflammatory response. S100A8 S100A9 associated with excessive cytokine storm play a decisive part within process inflammation. We aimed to clarify them in predicting prognosis hepatitis B virus-related ACLF (HBV-ACLF). Methods. levels were analyzed plasma 187 transplant-free HBV-ACLF patients, 28 healthy controls 40 chronic (CHB) patients. mRNAs checked samples 32 patients transplantation, 19 undergoing surgery for hepatic hemangioma 10 CHB needle biopsy. Results. higher than (S100A8 : P < 0.001 id="M2"> ) id="M3"> id="M4"> ), similar results obtained mRNA expression. Moreover, both proteins related grade, different types failure, infection, they correlated other prognostic scoring systems. can dependently predict 28/90-day (28-day: S100A8: hazard ratio (HR): 1.027; 95% confidence interval (CI): 1.007–1.048; id="M5"> = 0.026 , HR: 1.009; CI: 1.001–1.017; id="M6"> 0.007 90-day: 1.023; 1.011–1.035; id="M7"> 0.004 1.008; 1.004–1.012; id="M8"> ). Among all systems, combined model jointly Chronic Liver Failure-Consortium Organ Failure score (CLIF-C OFs)) displayed highest area under receiver operating curve (0.923 (95% CI, 0.887–0.961)) prediction 90-day mortality. Conclusions. promising biomarkers analysis risk stratification In addition, combining CLIF-C OFs may better ACLF.